Master/slave (MS) represents a revival of the en-face view, whereby the values of the first OCT/SLO are re-enacted using the modern principles of spectral (or Fourier) domain OCT.
It is a technical invention of Applied Optics Group at the University of Kent. Prof Adrian Podoleanu and Dr Adrian Bradu are the inventors of this new imaging technique.
Since then, MS-OCT has been used extensively for both imaging and dispersion study in the UBAPHODESA project.
A few key points of this new Master Slave OCT are:
- It operates like a time domain OCT, selecting signal from a selected depth while scanning the laser beam across the sample. Master Slave is a spectral (Fourier) domain OCT method, hence benefits from the sensitivity and speed advantage of the spectral (Fourier) domain methods in comparison with time domain method.
- This method allows collection of signals from any number of depths, as required by the user, i.e. of any number of en-face OCT images, from any depths, separated by any distance from the neighboring en-face slices.
- MS-OCT does not require resampling of data, hence no linearization, no calibration necessary, no clock needed in the swept source OCT, no linearized spectrometer in spectrometer based OCT
An illustration of MS-OCT technique in used for imaging pig embryo during early stage development. A 40 consecutive en-face (C-scan) can be viewed in one screen while simultaneous B-scan cross-section of the embryo is constructed at bottom right hand corner. (Image courtesy of Catherine Chin)
We have published a number of papers related to MS-OCT. This includes demonstration of technology and the application to clinical imaging by the UBAPHODESA team.
On clinical imaging:
- Catherine Chin, Adrian Bradu, Rongxuan Lim, Mona Khandwala, John Schofield, Lasse Leick, and Adrian Podoleanu, “Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma,” Appl. Opt. 55, 7378-7386 (2016) [External OSA site]
On demonstration of techniques:
- Sylvain Rivet, Michael Maria, Adrian Bradu, Thomas Feuchter, Lasse Leick, and Adrian Podoleanu, “Complex master slave interferometry,” Opt. Express 24, 2885-2904 (2016)
- Adrian Bradu, Michael Maria, and Adrian Gh. Podoleanu, “Demonstration of tolerance to dispersion of master/slave interferometry,” Opt. Express 23, 14148-14161 (2015)
Papers from original development by inventors at Kent with links to external resources:
- Adrian Bradu, Sylvain Rivet, and Adrian Podoleanu, “Master/slave interferometry – ideal tool for coherence revival swept source optical coherence tomography,” Biomed. Opt. Express 7, 2453-2468 (2016)
- Adrian Gh. Podoleanu and Adrian Bradu, “Master–slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography,” Opt. Express 21, 19324-19338 (2013)
- Adrian Gh. Podoleanu and Adrian Bradu, “Master–slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography,” Opt. Express 21, 19324-19338 (2013)
- Adrian Bradu, Konstantin Kapinchev, Frederick Barnes, and Adrian Podoleanu, “Master slave en-face OCT/SLO,” Biomed. Opt. Express 6, 3655-3669 (2015)
- Adrian Bradu and Adrian Gh. Podoleanu, “Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography,” Biomed. Opt. Express 5, 1233-1249 (2014)
- Adrian Bradu and Adrian Gh. Podoleanu, “Calibration-free B-scan images produced by master/slave optical coherence tomography,” Opt. Lett. 39, 450-453 (2014)
- Bradu A, Kapinchev K, Barnes F, Podoleanu A; “On the possibility of producing true real-time retinal cross-sectional images using a graphics processing unit enhanced master-slave optical coherence tomography system,” J. Biomed. Opt. 20(7), 076008 (2015)