May 3, 2016 admin

Magalie Bondu

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Project title, ESR5: Multi modal approaches and applications

Aiming to improve combined optical coherence tomography and multispectral photoacoustic microscopy by proving a single supercontinuum source suitable for simultaneous in-vivo imaging

Current projects and research areas

  • High power fiber lasers
  • Photonics crystal fibers and supercontinuum sources
  • Dual modality: photoacoutic microscopy (PAM)  and optical coherence tomography (OCT)
  • Multispectral PAM

 

Motivation

Photoacoutic microscopy (PAM) is based on tissues absorption, using a supercontinuum source is a ultra-broad band (typically 500-2400nm) may be relevant for multispectral PAM and permits to image multiple absorbers within a sample and give the oxygen saturation of the imaged blood vessels for instance. For PAM the supercontinuum source need to be filtered within a relatively small bandwidth (<50nm). However current supercontinuum sources have too low power to be used for multispectral PAM.

I worked at NKT Photonics on building a supercontinuum source with sufficient energy (>50nJ) and bandwidth (<20nm) for multispectral PAM. This single source has already proved its usefulness for multispectral PAM (<2nJ, <15nm) on ex-vivo retinal pigment epithelium and blood samples, and in-vivo PAM on a mouse ear (120nJ, 250nm). This supercontinuum source has been used as well for OCT on in-vivo mouse ears.

Recent developments were focused on making the supercontinuum source robust with sufficient energy for in-vivo combined multispectral PAM and OCT. The dual modality system is currently in the process of being build at the University of Kent.

 

Professional experience

  • December 2014 – December 2017
    Early stage Marie Curie researcher (UBAPHODESA, FP7-PEOPLE-2013-ITN, 607627) at NKT Photonics A/S (DK) and University of Kent (UK)
  • March 2014 – August 2014
    R&D internship in fiber lasers and LIDAR systems at Leosphere (FR)
  • June 2013 – August 2013
    Sales engineer internship in fiber lasers at Keopsys (DE)
  • September 2012 – February 2014
    Entrepreneurship education with start-up experience in lasers and nonlinear optics at Aimé Cotton and Charles Fabry Laboratories (FR)
  • July 2012
    Research internship in nonlinear optics at Charles Fabry Laboratory (FR)

 

Education

  • September 2012 – August 2014
    MSc in Laser, Optics and Matter, and Entrepreneurship at Institute of Optics Graduate School ParisTech (FR)
  • September 2008 – August 2011
    BSc in Math, Physics and Optics at Lycée H. Bergson (FR) and Institute of Optics Graduate School ParisTech (FR)
  • June 2008
    French Baccalaureat with honors

 

Publications

List of peer review publications

  1. Journal of Biomedical Optics 21 (6), 061005 (June 2016)
    • DOI: 1117/1.JBO.21.6.061005
    • Date of submission: 30 October 2015
    • Category: Special call paper with the Summer School Biophotonics’15
    • Published 2 February 2016
    • Title: “High energy supercontinuum sources using tapered photonic crystal fibers for multispectral photoacoustic microscopy“
    • Authors: Magalie Bondu, Christopher D. Brooks, Christian Jakobsen, Keith Oakes, Peter Morten Moselund, Lasse Leick, Ole Bang, Adrian Podoleanu
    • Abstract: We demonstrate a record bandwidth high energy supercontinuum source suitable for multispectral photoacoustic microscopy. The source has more than 150 nJ per 10 nm bandwidth over a spectral range of 500 nm to 1600 nm. This performance is achieved using a carefully designed fiber taper with large-core input for improved power handling and small-core output that provides the desired spectral range of the supercontinuum source.

 

  1. Optics Letters Vol. 41, No. 12, 2743-2746 (June 15 2016)
    • DOI: 1364/OL.41.002743
    • Date of submission: 6 April 2016
    • Accepted with minor revisions
    • Published 8 June 2016
    • Title: “Single all-fiber-based nanosecond-pulsed supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography“
    • Authors: Xiao Shu*, Magalie Bondu*, Biqin Dong, Adrian Podoleanu, Lasse Leick, Hao. F. Zhang (*equal contributions with the 1st author)
  • Abstract: We report the usefulness of a single all-fiber-based supercontinuum (SC) source for combined photoacoustic microscopy (PAM) and optical coherence tomography (OCT). The SC light is generated by a tapered photonic crystal fiber pumped by a nanosecond pulsed master oscillator power amplifier at 1064 nm. The spectrum is split into a shorter wavelength band (500– 800 nm) for single/multispectral PAM and a longer wavelength band (800– 900 nm) band for OCT. In vivo mouse ear imaging was achieved with an integrated dual-modality system. We further demonstrated its potential for spectroscopic photoacoustic imaging by doing multispectral measurements on retinal pigment epithelium and blood samples with 15-nm linewidth.

 

  1. Elsevier Photoacoustics (Gold open access) Vol. 9, 21-30 (2018)
    • DOI: 10.1016/j.pacs.2017.11.002
    • Date of submission: 21 august 2017
    • Accepted
    • Published 26 November 2017
    • Title: “Multispectral photoacoustic microscopy and optical coherence tomography using a single supercontinuum source“
    • Authors: Magalie Bondu, Manuel J. Marques, Peter M. Moselund, Gurprit Lall, Adrian Bradu, Adrian Podoleanu
    • Abstract: We report on the use of a single supercontinuum (SC) source for multimodal imaging. The 2-octave bandwidth (475-2300 nm) makes the SC source suitable for optical coherence tomography (OCT) as well as for multispectral photoacoustic microscopy (MPAM). The IR band centered at 1310 nm is chosen for OCT to penetrate deeper into tissue with 8 mW average power on the sample. The visible band is used for MPAM. The source is equipped with the ability to select the central wavelength as well as the spectral bandwidth. An energy of more than 35 nJ within a less than 50 nm bandwidth is achieved on the sample for wavelengths longer than 500 nm. In the present paper, we demonstrate the capabilities of such a multimodality imaging instrument based on a single optical source. In-vitro mouse ear B-scans images of a mouse ear are presented.

 

List of peer review conferences:

  1. Proceeding of SPIE-OSA, 10415, paper 1041507 (2017)
    • DOI: 1117/12.2286119
    • Date of submission: July 2017
    • Published 2017
    • Title: “Using a single supercontinuum source for visible multispectral photoacoustic microscopy and 1300 nm optical coherence tomography“
    • Authors: Magalie Bondu, Mark Denninger, Peter M. Moselund, Adrian Podoleanu
    • Abstract: We present a bimodal system driven by a supercontinuum source to perform photoacoustic-based spectral selective absorption measurements from 500 nm to 800 nm and structural optical coherence tomography imaging at 1300 nm. An energy of 5 to 40 nJ is achieved on sample within a 50 nm bandwidth in the visible range in the photoacoustic channel. Also, a few mW power is also achieved on the sample in the optical coherence tomography channel.

 

  1. Danish Opening Ceremony of the International Year of Light
    • Date: 22&23 January 2015
    • Place: DTU (Lyngby, DK)
    • Category: Poster presentation + Conference
    • Status: Accepted
    • Title: “High energy supercontinuum sources for photoacoustic imaging” (Introduction)
    • Authors: Magalie Bondu

 

  1. Biophotonics’15 Summer school
    • Date: 6-13 June 2015
    • Place: Ven (SE)
    • Category: Poster presentation + Summer School,
    • http://www.biop.dk/past-schools/2015
    • Title: “High energy supercontinuum sources for photoacoustic imaging
    • Authors: Magalie Bondu
    • Abstract: Supercontinuum sources are very suitable for many applications involving high resolution biophotonics imaging such as photoacoustic imaging. Using several wavelengths simultaneously, for example in the process of photoacoustic imaging, allows for more information to be acquired from a sample. However, at the moment the lack of pulse energy delivered by a supercontinuum source is an important limitation in improving system resolution and imaging depth. To generate a supercontinuum spectrum we pump a highly nonlinear fiber. Its small core size limits the input pulse energy and therefore the supercontinuum source output energy. Unfortunately we cannot use a larger core fiber since doing so will mitigate or fully prevent manifestation of the nonlinear effects needed to generate a broadband spectrum. The initial focus of this PhD project is to investigate the coupling of a supercontinuum pump source with relatively high peak power into a small core fiber without incurring damage to that fiber using, for example, tapered fiber.
    • Comments: special call from JBO with the summer school: paper 1

 

  1. Photonics West 2016
    • Date: 13&19 February 2016
    • Place: San Francisco (USA)
    • Category: Poster presentation + Conference + Exhibition, Spectroscopy and Analytic Sensing, session 15th Feburary 5:30 – 7:30 PM
    • Title: “Higher energy supercontinuum source suitable for photoacoustic microscopy“
    • Authors: Magalie Bondu, Christopher D. Brooks, Peter Morten Moselund, Lasse Leick, Adrian Podoleanu

 

  1. Photonics West 2016
    • Date: 13-18 February 2016
    • Place: San Francisco (USA)
    • Category: Oral presentation + Conference + Exhibition (post-deadline presentation)
    • Title: “A novel all fiber-based ns supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography“
    • Authors: Magalie Bondu, Xiao Shu, Biqin Dong, Lasse Leick, Adrian Podoleanu, Hao F. Zhang.
  1. Marie Skłodowska-Curie Action ESOF Satellite conference, Website: https://www.h2020.cz/files/perutkova/MSCA-ESOF-programme-July-2016.pdf, 28 – 29 Juny 2016
    • Date: 28-29 July 2016
    • Place: Manchester (UK),
    • Category: Poster
    • Title: ”UBAPHODESA – Ultrawide Bandwidth Photonics Devices, Sources and Applications”
    • Authors: Magalie Bondu, Sophie Caujolle, Felix Fleischhauer, Michael Maria, Lasse Leick, Thomas Feuchter and Adrian Podoleanu
  1. Photonics West 2017
    • Date: 28 January – 2 February 2017
    • Place: San Francisco (USA)
    • Category: Poster, https://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2017
    • Title: “Multimodal optical coherence tomography and multispectral photoacoustic microscopy with a single supercontinuum source: Studying the source noise“
    • Authors: Magalie Bondu, Peter M. Moselund, Lasse Leick, Adrian Podoleanu
  1. Functional scanning probe microscopy techniques (FSPM) conference (SEPnet),
    • Date: 30-31 March 2017
    • Place: Southampton (UK)
    • Category: Oral presentation + Conference
    • Title: “Single light source for multimodal imaging: Multispectral Photoacoustic Microscopy and Optical Coherence Tomography“
    • Authors: Magalie Bondu, Xiao Shu, Hao F. Zhang, Peter M. Moselund, Lasse Leick, Adrian Podoleanu
  1. World of Photonics Congress Munich: CLEO Europe, The European Conference on Lasers and Electro-Optics 2017, ISBN: 978-1-5090-6736-7, paper CJ_P_25
    • Date: 25-26 June 2017
    • Place: Munich (DE)
    • Category: Poster presentation + Conference + Exhibition
    • Title: “Development and noise study of an all fibre-based high energy supercontinuum source using tapered photonic crystal fibre for multimodalities“
    • Authors: Magalie Bondu, Peter M. Moselund, Adrian Podoleanu

10.World of Photonics Congress Munich: ECBO

  • Date: 25-26 June 2017
  • Place: Munich (DE)
  • Category: Oral presentation + Conference + Exhibition
  • Status: Accepted
  • Title: “Using a single supercontinuum source for visible multispectral photoacoustic microscopy and 1300 nm optical coherence tomography“
  • Authors: Magalie Bondu, Marc Denninger, Peter M. Moselund, Adrian Podoleanu

 

11. 2nd Canterbury Conference on OCT

  • Date: 6-8 September 2017
  • Place: University of Kent (UK)
  • Category: Oral presentation
  • Title: “Compact multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum source for tissue imaging“
  • Authors: Magalie Bondu, Adrian Bradu, Manuel J. Marques, Peter M. Moselund, Gurprit Lall, Adrian Podoleanu

12. Photonics West 2018

  • Date: 27 January – 1 February 2018
  • Place: San Francisco (USA)
  • Category: Poster
  • Status: Poster presented on 30th of January, session 6:00 – 8:00 PM
  • Title: “In-vitro 3D multispectral photoacoustic microscopy and optical coherence tomography using a supercontinuum source“
  • Authors: Magalie Bondu, Manuel J. Marques, Peter M. Moselund, Gurprit Lall, Adrian Bradu, Adrian Podoleanu

 

List of further attended conferences/workshops/events

 

  1. 1st UBAPHODESA workshop
    • Date: 24-25 Septembre 2015
    • Place: NKT (DK)
    • Category: Oral presentation
    • Title: “High energy supercontinuum source for photoacoustic microscopy“
    • Authors: Magalie Bondu

 

  1. Mid-term review
    • Date: 22 January 2016
    • Place: University of Kent, SPS (UK)
    • Category: Oral presentation
    • Title: “Multimodal approaches and applications“
    • Authors: Magalie Bondu

 

  1. SPS Postgraduate Colloquium
    • Date: 23 Septembre 2016
    • Place: University of Kent, SPS (UK)
    • Category: Oral presentation
    • Title: “Novel all-fibre-based supercontinuum light source for multimodal imaging“
    • Authors: Magalie Bondu, Xiao Shu, Hao F. Zhang, Peter M. Moselund, Lasse Leick, Adrian Podoleanu

 

  1. 2nd UBAPHODESA workshop
    • Date: 29-30 Septembre 2016
    • Place: University of Kent, SPS (UK)
    • Category: Oral presentation
    • Title: “All fiber-based supercontinuum source suitable for multispectral photoacoustic microscopy and OCT“
    • Authors: Magalie Bondu, Xiao Shu, Peter M. Moselund, Lasse Leick, Hao F. Zhang, Adrian Podoleanu

 

  1. Postgraduate Festival
    • Date: 16 May 2017
    • Place: University of Kent (UK)
    • Category: Photo presentation
    • Title: ”Multimodal Biomedical Imaging”
    • Authors: Magalie Bondu

 

  1. Postgraduate Festival
    • Date: 16 May 2017
    • Place: University of Kent (UK)
    • Category: 3MT (3min presentation)
    • Prize: Winner of the 3MT of the University of Kent, selected for the UK semi-final (not selected for the UK final)
    • Title: ”Multimodal imaging: a new vision for biomedical applications”
    • Authors: Magalie Bondu

 

  1. Maximise Your Research Impact
    • Date: 17 May 2017
    • Place: University of Kent (UK)
    • Category: Poster presentation
    • Title: “Multimodal optical coherence tomography and multispectral photoacoustic microscopy with a single supercontinuum source: Studying the source noise“
    • Authors: Magalie Bondu, Peter M. Moselund, Lasse Leick, Adrian Podoleanu
    • Comments: same poster than for Photonics West 2017

 

  1. EPSRC Image Guided Therapies Network+ meeting
    • Date: 7 July 2017
    • Place: Imperial College London (UK),
    • Category: Poster presentation
    • Title: “Multimodal imaging using a single light source“
    • Authors: Magalie Bondu, Manuel J. Marques, Peter M. Moselund, Adrian Bradu, Adrian Podoleanu

 

  1. FINS 2017 Colloquium
    • Date: 15-18 Octobre 2017
    • Place: Bordeaux (FR),
    • Category: Poster presentation
    • Title: “Bio-imaging using supercontinuum sources“
    • Authors: Magalie Bondu, Sophie Caujolle, Felix Fleischhauer, Thomas Ferhat, Thomas Feuchter, Adrian Podoleanu

 

  • Workshop: Leadership and diversity in organisations, School of Psychology, University of Kent (8 September 2016, UK).